Drugs and Lipids

Antihypertensive drugs and plasma lipids.

Effects of Lipids on Absorption of Poorly Water-Soluble Drugs

Introduction Although the capability of ingested lipids to enhance the bioavailability of poorly water-soluble drugs has been experimentally observed and established 1 , the phenomenon is not well understood and is unpredictable. Commercially, lipids could offer valuable opportunities for enabling oral drug delivery, as approximately 4070% of all new drug candidates have been estimated to have ...

Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs.

Lipids have the potential for development as anticancer agents. Endogenous membrane lipids, such as ceramides and certain saturated fatty acids, have been found to modulate the viability of tumor cells. In addition, many tumors over-express cyclooxygenase, lipoxygenase or cytochrome P450 enzymes that mediate the biotransformation of ω-6 polyunsaturated fatty acids (PUFAs) to potent eicosanoid r...

No Association between Serum Lipids Levels and Lipids Oxidizability in Type 2 Diabetes

Objective: Diabetes is the most common metabolic disease. One of the most common problems in diabetic patients is atherosclerotic cardiovascular disease which induced by hyperlipidemia. Also there has been currently great interest in the potential contribution of oxidative stress in development of diabetes complications. The present study was performed to associate between lipid oxidizability a...

Conversion from enzyme-inducing antiepileptic drugs to topiramate: effects on lipids and C-reactive protein.

PURPOSE We previously demonstrated that converting patients from the enzyme-inducers phenytoin or carbamazepine to the non-inducers levetiracetam or lamotrigine reduces serum lipids and C-reactive protein (CRP). We sought to determine if the same changes would occur when patients were switched to topiramate, which has shown some evidence of enzyme induction at high doses. We also examined the e...